| Chemical Properties | Di-tert-butyl dicarbonate (BOC Anhydride, DiBOC) ndi makristalo opanda mtundu mpaka oyera mpaka achikasu, olimba olimba kapena madzi owoneka bwino.Imasungunuka mozungulira kutentha (mp=23°C).Simawola pamenepa kapena ngakhale kutentha pang'ono.Mwachitsanzo, nthawi zambiri amayeretsedwa ndi distillation pansi pa kupanikizika kochepa pa kutentha mpaka pafupifupi 65 ° C.Kutentha kwambiri kumawola kukhala isobutene, t-butyl mowa ndi carbon dioxide. |
| Ntchito | Di-tert-butyl dicarbonate (Boc2O) ndi reagent yomwe imagwiritsidwa ntchito kwambiri poyambitsa magulu oteteza mu kaphatikizidwe ka peptide.Zimagwira ntchito yofunika kwambiri pokonzekera 6-acetyl-1,2,3,4-tetrahydropyridine pochita ndi 2-piperidone.Imagwira ntchito ngati gulu loteteza lomwe limagwiritsidwa ntchito popanga gawo lolimba la peptide. |
| Kukonzekera | Kukonzekera kwa Di-tert-butyl dicarbonate ndi motere: Kuti monoester sodium mchere njira anawonjezera 2g wa N, N-dimethylformamide, 1g wa pyridine, 1g wa triethylamine, Kuzirala kwa -5 ~ 0 ° C, 60g diphosgene anali pang`onopang`ono. Anawonjezera dropwise mkati 1.5h dropwise Kuwonjezera anali wathunthu, anatenthetsa kwa firiji (25 ° C), chofungatira kwa 2h, anachita analoledwa kuima pambuyo kusefera, kutsuka organic njira.Zowumitsidwa ndi anhydrous magnesium sulfate, zosungunulirazo zidasungunulidwa ndi mphamvu ya mumlengalenga kuti zipereke zinthu zopanda pake 65 ~ 70g.Pambuyo pozizira ndi crystallization, 57-60g ya di-tert-butyl dicarbonate inapezedwa mu zokolola za 60-63%. |
| Tanthauzo | ChEBI: Di-tert-butyl dicarbonate ndi acyclic carboxylic anhydride.Zimagwira ntchito mogwirizana ndi dicarbonic acid. |
| Zochita | Zochita za anilines olowetsedwa ndi Boc2O pamaso pa kuchuluka kwa stoichiometric kwa 4-dimethylaminopyridine (DMAP) mu zosungunulira za inert (acetonitrile, dichloromethane, ethyl acetate, tetrahydrofuran, toluene) kutentha kwachipinda kumatsogolera ku aryl isocyanates pafupifupi mkati mwa kuchuluka kwa 10 min.
Di-tert-butyl dicarbonate ndi 4-(dimethylamino) pyridine adasinthidwanso.Zochita zawo ndi ma amines ndi mowa |
| Kufotokozera Kwambiri | Di-tert- butyl dicarbonate (Boc2O) ndi reagent yomwe imagwiritsidwa ntchito makamaka poyambitsa gulu loteteza la Boc kuti amine magwiridwe antchito.Amagwiritsidwanso ntchito ngati mankhwala ochepetsa madzi m'thupi pazachilengedwe, makamaka ndi ma carboxylic acid, magulu ena a hydroxyl, kapena ndi ma nitroalkanes oyambira. |
| Zowopsa | Kukwiyitsa komwe kungayambitse vuto lalikulu la maso;Zingayambitse khungu tcheru;Ndiwowopsa kwambiri pokoka mpweya |
| Kutentha ndi Kuphulika | Zoyaka |
| Njira Zoyeretsera | Sungunulani ester potenthetsa pa ~ 35o, ndi kuisungunula mu vacuum.Ngati IR ndi NMR ( 1810m 1765 cm-1 , mu CCl4 1.50 singlet) akusonyeza kuti ndi zonyansa kwambiri, ndiye kusamba ndi wofanana buku la H2O munali citric asidi kuti amadzimadzi wosanjikiza pang'ono acidic, sonkhanitsani organic wosanjikiza ndi kuumitsa pa anhydrous MgSO4. ndi kuwasungunula mu vacuum.[Papa et al.Org Synth 57 45 1977, Keller et al.Org Synth 63 160 1985, Grehn et al.Angew Chem 97 519 1985.] ZOYALETSA. |
