N-Methyl-2-pyrrolidone

Kufotokozera Kwachidule:

Dzina lazogulitsa:N-Methyl-2-pyrrolidone

Mawu ofanana ndi mawu:M-PYROL(R); 1-Methyl-2-pyrrolidinone(99.5%, HyDry, Water≤50 ppm (ndi KF));1-Methyl-2-pyrrolidinone(99.5%, HyDry, ndi sieves molecular, Water≤50) ppm (ndi KF)); Wopanga N-Methyl-2-pyrrolidone;1-METHYL-2-PYRROLIDONE, REAGENT (ACS)1-METHYL-2-PYRROLIDONE, REAGENT (ACS)1-METHYL-2-PYRROLIDONE, REAGENT ( ACS);1-Methyl-2-pyrrolidinone 872-50-4 NMP N-Methyl-2-pyrrolidinone;N-Methyl-2-pyrrolidinone 872-50-4 NMP;1-METHYL-2-PYRROLIDINONE

CAS:872-50-4

MF:C5H9NO

MW:99.13

EINECS:212-828-1

Magulu azinthu:NMP;Chemical raw materials;UV/Vis);GC Headspace Solvents;GC Solvents;solvents for GC applications;ACS and Reagent Grade Solvents;ACS Grade;ACS Grade Solvents;Carbon Steel Cans with NPT Threads;Heavy Metals;Solvents for LC- ICP-MS;Poizoni (kupatulapo mankhwala ophera tizilombo/zotsalira za mankhwala);Mapulogalamu;Kusanthula kwa Chakumwa;Mitsuko Yomanga;C4 mpaka C8;Kaphatikizidwe ka Chemical;Chakudya &;GC-MS Solvents;Heterocyclic Building Blocks;ICP-OES/-MS;Pyrrolidines; Ma reagents for Inorganic Trace Analysis;Zosungunulira za Chitsulo Speciation Analysis;Zosungunulira za Speciation Analysis (LC-ICP-MS);Spectroscopy;Trace Analysis Reagents &;Anhydrous;Products;Mabotolo osungunulira;Amines;Heterocycles;Miscellaneous Reagents;Anhydrous Solvents; Ntchito;Njira Zina;Mabotolo a Amber Glass;Analytical Reagents;Analytical/Chromatography;CHROMASOLV Plus;Chromatography Reagents &;Electrolytes;HPLC &;HPLC Plus Grade Solvents (CHROMASOLV);HPLC/UHPLC Solvents (CHROMASOLV;NOLV);Materials Products Science Organic Solvents;Mabotolo a Semi-Bulk Solvents;Mabotolo osungunula;Zosankha Zosungunulira;UHPLC Solvents (CHROMASOLV);NMR;Galasi la Spectrophotometric;Zosungunulira za Spectrophotometric;Zosungunulira za Spectroscopy (IR;Mabotolo Obweza;Mabotolo a Sure/Seal;Bioventes;Bioventes; ;Ndithu/Kusindikiza?Mabotolo;872-50-4;bc0001

Fayilo ya Mol:872-50-4.mol

Titumizireni imelo

Tsatanetsatane wa Zamalonda

Zogulitsa Tags

Malingaliro a kampani Pyrrolidone Chemical Properties

Malo osungunuka	-24 °C (kuyatsa)
Malo otentha	202 °C (kuyatsa) 81-82 °C/10 mmHg (kuyatsa)
kachulukidwe	1.028 g/mL pa 25 °C (kuyatsa)
kachulukidwe ka nthunzi	3.4 (vs mpweya)
kuthamanga kwa nthunzi	0.29 mm Hg (20 °C)
refractive index	n20/D 1.479
Fp	187 °F
kutentha kutentha.	Sungani pa +5 ° C mpaka +30 ° C.
kusungunuka	ethanol: miscible0.1ML/mL, yomveka, yopanda mtundu (10%, v/v)
mawonekedwe	Madzi
pka	-0.41±0.20(Zonenedweratu)
mtundu	≤20(APHA)
PH	8.5-10.0 (100g/l, H2O, 20℃)
Kununkhira	Kununkhira kwa amine pang'ono
Mtundu wa PH	7.7 - 8.0
malire ophulika	1.3-9.5% (V)
Kusungunuka kwamadzi	> = 10 g/100 mL pa 20 ºC
Zomverera	Hygroscopic
λ max	283nm(MeOH)(lit.)
Merck	14,6117
Mtengo wa BRN	106420
Kukhazikika:	Wokhazikika, koma amawola akamva kuwala.Zoyaka.Zosagwirizana ndi ma oxidizing amphamvu, ma asidi amphamvu, ochepetsera, maziko.
InChIKey	SECXISVLQFMRJM-UHFFFAOYSA-N
LogP	-0.46 pa 25 ℃
CAS DataBase Reference	872-50-4 (CAS DataBase Reference)
NIST Chemistry Reference	2-Pyrrolidinone, 1-methyl-(872-50-4)
EPA Substance Registry System	N-Methyl-2-pyrrolidone (872-50-4)

Zambiri Zachitetezo

Zizindikiro Zowopsa	T, Xi
Ndemanga Zowopsa	45-65-36/38-36/37/38-61-10-46
Ndemanga za Chitetezo	41-45-53-62-26
WGK Germany	1
Mtengo wa RTECS	UY5790000
F	3-8-10
Kutentha kwa Autoignition	518 °F
TSCA	Y
HS kodi	2933199090
Zambiri Zazinthu Zowopsa	872-50-4 (Deta Yowopsa)
Poizoni	LD50 pakamwa pa Kalulu: 3598 mg/kg LD50 dermal Kalulu 8000 mg/kg

Kugwiritsa Ntchito Pyrrolidone Ndi Kaphatikizidwe

Chemical Properties	N-Methyl-2-pyrrolidone ndi madzi owonekera achikasu owoneka bwino komanso onunkhira pang'ono ammonia.N-Methyl-2-pyrrolidone imasakanikirana ndi madzi.Amasungunuka kwambiri mu zakumwa zoledzeretsa, ma ketones otsika, ether, ethyl acetate, chloroform, ndi benzene ndipo amasungunuka bwino mu aliphatic hydrocarbons.N-Methyl-2-pyrrolidone ndi ya hygroscopic kwambiri, yokhazikika pamankhwala, yosawononga ku carbon steel ndi aluminiyamu, ndipo imawononga pang'ono mkuwa.Imakhala ndi zomatira zochepa, kukhazikika kwamankhwala amphamvu komanso kutentha, polarity yayikulu, komanso kusinthasintha kochepa.Izi ndizowopsa pang'ono, ndipo malire ake ovomerezeka mumlengalenga ndi 100ppm. N-Methyl-2-pyrrolidone ndi zosungunulira zomwe zimagwiritsidwa ntchito m'mafakitale ndi ntchito zosiyanasiyana, monga kuchotsa utoto ndi zokutira, petrochemical processing, zokutira zapulasitiki zaumisiri, mankhwala aulimi, kuyeretsa zamagetsi ndi mafakitale / kunyumba.
Ntchito	N-Methyl-2-pyrrolidone (NMP) ndi polar aprotic zosungunulira zomwe zili ndi ubwino wa kawopsedwe kakang'ono, malo otentha kwambiri, kusungunuka kwapadera, kusankha kwakukulu ndi kukhazikika kwabwino.Amagwiritsidwa ntchito kwambiri pakuyeretsa kutulutsa konunkhira kwa hydrocarbon, acetylene, olefins, ndi diolefins. Amagwiritsidwa ntchito poyeretsa m'mafakitale, ndipo amagwira ntchito ngati chosungunulira popanga mankhwala ophera tizilombo, mapulasitiki opangira uinjiniya, zokutira, ulusi wopangira, ndi mabwalo ophatikizika. Itha kugwiritsidwanso ntchito ngati chotsukira mafakitale, dispersant, utoto, lubricant ndi antifreeze. N-Methyl-2-pyrrolidone ndi zosungunulira zabwino kwambiri, zomwe zimagwiritsidwa ntchito kwambiri pochotsa aromatics, kuyenga mafuta opaka mafuta, kulimbikitsa acetylene, kulekanitsa butadiene ndi synthesis gas desulfurization. Amagwiritsidwa ntchito mu gasi desulfurization, lubricating mafuta kuyenga, lubricating mafuta antifreeze, olefin m'zigawo, ndi monga zosungunulira kwa insoluble engineering mapulasitiki polymerization. Itha kugwiritsidwa ntchito mu herbicide, kuyeretsa zida zotchinjiriza, zida zolondola zamakampani a semiconductor ndi matabwa ozungulira, kukonzanso utsi wa PVC, ngati chotsukira, chowonjezera cha utoto ndi chothandizira kubalalitsa. Amagwiritsidwa ntchito m'njira zopangira ma polymerization monga mapulasitiki a engineering ndi fiber aramid. N-Methyl-2-pyrrolidone amagwiritsidwa ntchito ngati polyvinylidene fluoride zosungunulira ndi elekitirodi wothandiza zakuthupi kwa lithiamu ion mabatire. chiyero chapamwamba cha kuzindikira kwa ICP-MS. Kwa peptide synthesis.
kawopsedwe	Oral (mus)LD50:5130 mg/kg;Mkamwa (khoswe)LD50:3914 mg/kg;Dermal (rbt)LD50:8000 mg/kg.
Kutaya Zinyalala	Fufuzani malamulo a boma, am'deralo kapena adziko kuti athetsedwe moyenera.Kutaya kuyenera kupangidwa motsatira malamulo ovomerezeka.Madzi, ngati kuli kofunikira ndi oyeretsa.
yosungirako	N-Methyl-2-pyrrolidone ndi hygroscopic (imatenga chinyezi) koma imakhala yokhazikika pansi pazikhalidwe.Idzachita mwachiwawa ndi oxidizers amphamvu monga hydrogen peroxide, nitric acid, sulfuric acid, ndi zina zotero. Zoyamba zowonongeka zimatulutsa mpweya wa carbon monoxide ndi mpweya wa nitrogen oxide.Kuwonekera kwambiri kapena kutayikira kuyenera kupewedwa ngati njira yabwino.Lyondell Chemical Company imalimbikitsa kuvala magolovesi a butyl mukamagwiritsa ntchito N-Methyl-2-pyrrolidone.N-Methyl-2-pyrrolidone iyenera kusungidwa muzitsulo zoyera, zokhala ndi phenolic zofewa kapena ng'oma za aloyi.Teflon®1 ndi Kalrez®1 awonetsedwa kuti ndi zida zoyenera za gasket.Chonde onaninso MSDS musanagwire.
Kufotokozera	N-Methyl-2-pyrrolidone ndi aprotic solvent ndi ntchito zosiyanasiyana: petrochemical processing, kupaka pamwamba, utoto ndi inki, mafakitale ndi kuyeretsa m'nyumba mankhwala, ndi ulimi ndi mankhwala formulations.Imakwiyitsa kwambiri, koma idayambitsanso milandu ingapo yokhudzana ndi dermatitis mumakampani ang'onoang'ono a electrotechnical.
Chemical Properties	N-Methyl-2-pyrrolidone ndi madzi opanda mtundu kapena opepuka achikasu okhala ndi fungo la amine.Ikhoza kuchitidwa ndi mankhwala angapo ngakhale kuti imavomerezedwa ngati chosungunulira chokhazikika.Imagonjetsedwa ndi hydrolysis pansi pazandale, koma asidi amphamvu kapena chithandizo chapansi chimabweretsa kutsegulidwa kwa mphete ku 4-methyl aminobutyric acid.N-Methyl-2-pyrrolidone ikhoza kuchepetsedwa kukhala 1-methyl pyrrolidine ndi borohydride.Kuchiza ndi mankhwala ophera chlorine kumabweretsa mapangidwe a amide, apakati omwe angalowe m'malo, pomwe mankhwala a amyl nitrate amatulutsa nitrate.Olefins akhoza kuwonjezeredwa ku malo a 3 mwa chithandizo choyamba ndi oxalic esters, ndiye ndi aldehyes yoyenera (Hort ndi Anderson 1982).
Ntchito	N-Methyl-2-pyrrolidone ndi chosungunulira cha polar chomwe chimagwiritsidwa ntchito mu organic chemistry ndi polymer chemistry.Ntchito zazikuluzikulu zikuphatikizapo kubwezeretsa ndi kuyeretsa kwa acetylenes, olefins, ndi diolefins, kuyeretsa gasi, ndi kuchotsa aromatics kuchokera ku feedstocks.N-Methyl-2-pyrrolidone ndi zosungunulira zamagulu osiyanasiyana.NMP pakadali pano ndiyovomerezeka kuti igwiritsidwe ntchito m'zamankhwala azinyama.Kutsimikiza kwa kagayidwe kake ndi kagayidwe ka NMP mu makoswe kumathandizira kumvetsetsa kaphatikizidwe ka mankhwala akunjawa omwe munthu angakumane nawo pakuchulukirachulukira.
Ntchito	Kusungunula kwa utomoni wotentha kwambiri;kukonza petrochemical, mumakampani opanga ma microelectronics, utoto ndi utoto, mafakitale ndi zoyeretsa m'nyumba;zaulimi ndi mankhwala formulations
Ntchito	N-Methyl-2-pyrrolidone, ndiyothandiza pa spectrophotometry, chromatography ndi kuzindikira kwa ICP-MS.
Tanthauzo	ChEBI: Membala wa gulu la pyrrolidine-2-omwe ndi pyrrolidin-2-imodzi momwe haidrojeni yomwe imayikidwa ku nayitrogeni imasinthidwa ndi gulu la methyl.
Njira Zopangira	N-Methyl-2-pyrrolidone amapangidwa ndi zomwe buytrolactone ndi methylamine (Hawley 1977).Njira zina zimaphatikizapo kukonzekera ndi hydrogenation ya mayankho a maleic kapena succinic acid ndi methylamine (Hort ndi Anderson 1982).Opanga mankhwalawa akuphatikizapo Lachat Chemical, Inc, Mequon, Wisconsin ndi GAF Corporation, Covert City, California.
Zolozera za kaphatikizidwe	Makalata a Tetrahedron, 24, p.1323, 1983DOI: 10.1016/S0040-4039(00)81646-9
Kufotokozera Kwambiri	N-Methyl-2-Pyrrolidone (NMP) ndi mphamvu, aprotic zosungunulira ndi high solvency, ndi low volatility.Izi zopanda mtundu, zowira kwambiri, zonyezimira komanso mpweya wochepa wamadzimadzi zimakhala ndi fungo lochepa ngati amine.NMP ili ndi kukhazikika kwa mankhwala ndi kutentha ndipo imasakanikirana ndi madzi pa kutentha kulikonse.NMP imatha kukhala yosungunulira pamodzi ndi madzi, ma alcohols, glycol ethers, ketoni, ndi ma hydrocarbon onunkhira/oyera.NMP imatha kubwezeretsedwanso pogwiritsa ntchito distillation komanso imatha kuwonongeka mosavuta.NMP sichipezeka pa mndandanda wa Zowononga Mpweya Zowopsa (HAPs) za 1990 Clean Air Act Amendments.
Zotsatira za Air & Madzi	Zosungunuka m'madzi.
Mbiri ya Reactivity	Amine uyu ndi wofatsa kwambiri wamankhwala.N-Methyl-2-pyrrolidone amakonda kusokoneza ma acid kuti apange mchere kuphatikiza madzi.Kuchuluka kwa kutentha komwe kumasinthika pa mole ya amine mu neutralization makamaka sikudalira mphamvu ya amine monga maziko.Amines angakhale osagwirizana ndi isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, ndi asidi halides.Mafuta oyaka moto wa haidrojeni amapangidwa ndi ma amines kuphatikiza ndi zochepetsera zolimba, monga ma hydrides.
Zowopsa	Khungu kwambiri ndi maso.Malire ophulika - 2.2-12.2%.
Ngozi Yaumoyo	Kukoka mpweya wa nthunzi yotentha kumatha kukhumudwitsa mphuno ndi mmero.Kudya kumayambitsa kupsa mtima m'kamwa ndi m'mimba.Kukhudzana ndi maso kumayambitsa mkwiyo.Kukhudzana kobwerezabwereza komanso kwanthawi yayitali kumatulutsa mkwiyo wocheperako.
Moto Wowopsa	Zowopsa Zapadera Zazinthu Zoyaka: Ma toxic oxide a nayitrogeni amatha kupangidwa pamoto.
Kutentha ndi Kuphulika	Zosayaka
Zogwiritsa ntchito mafakitale	1) N-Methyl-2-pyrrolidone imagwiritsidwa ntchito monga dipolar aprotic solvent, yokhazikika komanso yosasunthika; 2) pochotsa ma hydrocarbons onunkhira kuchokera kumafuta opaka mafuta; 3) kuchotsa mpweya woipa mu ammonia jenereta; 4) monga zosungunulira kwa polymerization zimachitikira ndi ma polima; 5) ngati chovula utoto; 6) pakupanga mankhwala ophera tizilombo (USEPA 1985). Ntchito zina zosagwiritsidwa ntchito m'mafakitale za N-Methyl-2-pyrrolidone zimachokera kuzinthu zake monga zosungunulira zowonongeka zoyenera pa maphunziro a electrochemical ndi thupi (Langan ndi Salman 1987).Mankhwala ntchito ntchito katundu wa N-Methyl-2-pyrrolidone ngati malowedwe enhancer kwa kutengerapo mofulumira zinthu kudzera pakhungu (Kydoniieus 1987; Barry ndi Bennett 1987; Akhter ndi Barry 1987).N-Methyl-2-pyrrolidone yavomerezedwa ngati chosungunulira cha slimicide application ku zinthu zopangira chakudya (USDA 1986).
Lumikizanani ndi ma allergen	N-Methyl-2-pyrrolidone ndi aprotic solvent ndi ntchito zosiyanasiyana: petrochemical processing, kupaka pamwamba, utoto ndi inki, mafakitale ndi kuyeretsa m'nyumba mankhwala, ndi ulimi ndi mankhwala formulations.Nthawi zambiri imakwiyitsa, koma imatha kuyambitsa kukhudzana kwambiri ndi dermatitis chifukwa cholumikizana kwanthawi yayitali.
Mbiri Yachitetezo	Poizoni kudzera m'mitsempha.Poizoni pang'ono pomeza ndi intraperitoneal njira.Poizoni pang'ono pokhudzana ndi khungu.Teratogen yoyesera.Zoyeserera zoberekera.Zosintha zasintha.Imatha kuyaka ikayatsidwa ndi kutentha, lawi lotseguka, kapena ma oxidizer amphamvu.Kulimbana ndi moto, gwiritsani ntchito thovu, CO2, mankhwala owuma.Ikatenthedwa kuti iwonongeke imatulutsa mpweya woipa wa NOx.
Carcinogenicity	Makoswe adawonetsedwa ndi nthunzi ya N-Methyl-2-pyrrolidone pa 0, 0.04, kapena 0.4 mg / L kwa 6 h / tsiku, masiku 5 / sabata kwa zaka 2. Makoswe amphongo pa 0.4 mg / L amasonyeza kuchepa pang'ono kulemera kwa thupi.Palibe zotsatira zofupikitsa zapoizoni kapena carcinogenic zomwe zidawonedwa mu makoswe owululidwa kwa zaka 2 mpaka 0.04 kapena 0.4mg/L ya N-Methyl-2-pyrrolidone.Mwa njira ya dermal, gulu la mbewa za 32 linalandira mlingo woyambira wa 25mg wa N-Methyl-2-pyrrolidone pambuyo pa masabata a 2 ndi ntchito za chotupa cholimbikitsa phorbol myristate acetate, katatu pa sabata, kwa masabata oposa 25.Dimethylcarbamoyl chloride ndi dimethylbenzanthracene adagwira ntchito ngati zowongolera zabwino.Ngakhale gulu la N-Methyl-2-pyrrolidone linali ndi zotupa zapakhungu zitatu, kuyankha kumeneku sikunali kofunika kwambiri poyerekeza ndi zowongolera zabwino.
Njira ya metabolic	Makoswe amaperekedwa ndi wailesi yotchedwa N-methyl-2-pyrrolidinone (NMP), ndipo njira yaikulu yotulutsira makoswe ndi mkodzo.Metabolite yayikulu, yomwe imayimira 70-75% ya mlingo woperekedwa, ndi 4-(methylamino) butenoic acid.Izi unsaturated intact mankhwala akhoza kupangidwa kuchokera kuchotsa madzi, ndipo gulu hydroxyl akhoza kupezeka pa metabolite pamaso asidi hydrolysis.
Metabolism	Makoswe amphongo a Sprague-Dawley anapatsidwa jekeseni imodzi ya intraperitoneal (45 mg / kg) ya radiolabeled 1 -methyl-2-pyrrolidone.Miyezo ya plasma ya radioactivity ndi kaphatikizidwe idayang'aniridwa kwa maola asanu ndi limodzi ndipo zotsatira zake zidawonetsa gawo logawa mwachangu lomwe lidatsatiridwa ndi gawo lochotsa pang'onopang'ono.Kuchuluka kwa chizindikirocho kunatulutsidwa mumkodzo mkati mwa maola 12 ndipo kunawerengera pafupifupi 75% ya mlingo wotchulidwa.Maola makumi awiri ndi anayi mutatha kumwa, kuchuluka kwa mkodzo (mkodzo) kunali pafupifupi 80% ya mlingo.Mitundu yonse yokhala ndi mphete ndi methyl idagwiritsidwa ntchito, komanso zonse ziwiri [¹⁴C] - ndi [3H] -yotchedwa l-methyl-2-pyrrolidone.Magawo oyamba olembedwa adasungidwa m'maola 6 oyamba mutatha kumwa.Pambuyo pa maola 6, chiwindi ndi matumbo adapezeka kuti ali ndi ma radioactivity apamwamba kwambiri, pafupifupi 2-4% ya mlingo.Ma radioactivity ochepa adadziwika mu bile kapena mpweya wopumira.High ntchito madzi chromatography mkodzo anasonyeza kukhalapo kwa chimodzi chachikulu ndi ziwiri zazing'ono metabolites.Metabolite yayikulu (70-75% ya mlingo woyendetsedwa ndi radioactive) idawunikidwa ndi madzi chromatography-mass spectrometry ndi gas chromatography-mass spectrometry ndipo idapangidwa kuti ikhale 3- kapena 5-hydroxy-l-methyl-2-pyrrolidone (Wells). 1987).
Njira Zoyeretsera	Yanikani pyrrolidone pochotsa madzi ngati benzene azeotrope.Pang'onopang'ono distil pa 10 torr kudzera pa 100-cm ndime yodzaza ndi magalasi agalasi.[Adelman J Org Chem 29 1837 1964, McElvain & Vozza J Am Chem Soc 71 896 1949.] Hydrochloride ili ndi m 86-88o (kuchokera ku EtOH kapena Me2CO/EtOH) [Reppe et al.Justus Liebigs Ann Chem 596 1 1955].[Beilstein 21 II 213, 21 III/IV 3145, 21/6 V 321.]