Zogulitsa
Pyrimidine-2,4 (1H,3H) -dione
Mawu ofanana ndi mawu:Urasili
Mankhwala Katundu wa Pyrimidine-2,4 (1H, 3H) -Dione
● Maonekedwe/ Mtundu: ufa woyera
● Kuthamanga kwa Nthunzi:2.27E-08mmHg pa 25°C
● Malo Osungunuka:>300 °C(lit.)
● Refractive Index: 1.501
● Malo Owira: 440.5 ° C pa 760 mmHg
● PKA:9.45(pa 25℃)
● Flash Point: 220.2oC
● PSA:65.72000
● Kuchulukana: 1.322 g/cm3
● LogP: -0.93680
● Kutentha Kwambiri: +15C mpaka +30C
● Kusungunuka.: Aqueous Acid (Pang'ono), DMSO (Pang'ono, Kutentha, Sonicated), Methanol (Pang'ono,
● Kusungunuka kwa Madzi.:KUsungunuka M'MADZI OTSATIRA
● XLogP3:-1.1
● Nambala Yopereka Bondi ya Hydrogen:2
● Kuwerengera kwa Hydrogen Bond Acceptor:2
● Kuwerengera Bond Yosinthasintha: 0
● Misa Yeniyeni:112.027277375
● Kuwerengera Atomu Yolemera:8
● Kuvuta kwake:161
Safty Information
● Zithunzi:
Xi
● Zizindikiro Zowopsa:Xi
● Malangizo a Chitetezo: 22-24/25
Zothandiza
Maphunziro a Chemical:Biological Agents -> Nucleic Acid ndi Zotumphukira
Canonical SMILES:C1=CNC(=O)NC1=O
Mayesero aposachedwa a Clinical:Kafukufuku wa 0.1% Uracil Topical Cream (UTC) for Prevention of Hand-Foot Syndrome
Mayesero aposachedwa a EU Clinical:Onderzoek naar de farmacokinetiek van uracil ndi orale toediening bij pati?nten met colorectaal carcinoom.
Mayesero aposachedwapa a NIPH Clinical: Gawo lachiwiri la mayesero a mafuta a uracil pofuna kupewa capecitabine induced hand-foot syndrome (HFS):.
Zogwiritsa:Kwa kafukufuku wam'chilengedwe, kaphatikizidwe ka mankhwala; amagwiritsidwa ntchito ngati mankhwala apakatikati, amagwiritsidwanso ntchito popanga organic synthesis ya nayitrogeni pa RNA nucleosides. antineoplastic Mu kafukufuku wa biochemical. Uracil (Lamivudine EP Impurity F) ndi maziko a nayitrogeni pa RNA nucleosides.
Kufotokozera:Uracil ndi maziko a pyrimidine komanso gawo lofunikira la RNA pomwe limamangiriza ku adenine kudzera pa ma hydrogen bond. Imasinthidwa kukhala nucleoside uridine kudzera pakuphatikiza kwa ribose moiety, kenako nucleotide uridine monophosphate powonjezera gulu la phosphate.
Mawu Oyamba Mwatsatanetsatane
Uracil ndi organic pawiri yomwe ili m'gulu la zotumphukira za pyrimidine. Ndi molekyulu yonunkhira ya heterocyclic yokhala ndi mphete ya pyrimidine yokhala ndi maatomu awiri oyandikana nawo a nayitrogeni. Uracil ili ndi formula yamankhwala C4H4N2O2 ndi molekyulu yolemera 112.09 g/mol.
Uracil ndi imodzi mwa nucleobases inayi yomwe imapezeka mu chibadwa cha RNA (ribonucleic acid). Zimagwira ntchito yofunika kwambiri pakupanga mapuloteni komanso ma jini. Mu RNA, ma uracil awiriawiri okhala ndi adenine kudzera pa hydrogen bonding, kupanga zomangira ziwiri za haidrojeni, ndipo kuphatikizika koyambira kumeneku kumathandiza kubisa zambiri za majini.
Uracil amapezekanso m'mamolekyu ena ofunikira achilengedwe. Mwachitsanzo, ndi gawo lofunikira la molekyulu yonyamula mphamvu yotchedwa ATP (adenosine triphosphate). Zochokera ku Uracil, monga 5-fluorouracil, zakhala zikugwiritsidwa ntchito ngati mankhwala oletsa khansa chifukwa cha kuthekera kwawo kusokoneza kubwereza kwa DNA ndi kugawanika kwa maselo.
Kuphatikiza pa kufunikira kwake kwachilengedwe, uracil imakhala ndi mankhwala osiyanasiyana komanso mafakitale. Amagwiritsidwa ntchito ngati poyambira pakupanga mankhwala, agrochemicals, ndi utoto. Zochokera ku Uracil zimagwiritsidwanso ntchito popanga herbicides ndi fungicides. Kuphatikiza apo, uracil atha kugwiritsidwa ntchito ngati cholembera mu analytical chemistry komanso ngati chida pakufufuza kwa ma cell biology.
Uracil ndi cholimba cha crystalline choyera chomwe chimasungunuka pang'ono m'madzi. Imakhala yokhazikika pamikhalidwe yabwinobwino koma imatha kukumana ndi ma chemical reaction, monga ma oxidation and substitution reactions, pamikhalidwe inayake. Pagululi ali ndi malo osungunuka a 335-338°C ndi malo otentha a 351-357°C.
Ponseponse, uracil ndi gawo lofunikira kwambiri pazachilengedwe za RNA ndipo imakhala ndi ntchito zofunikira m'mafakitale achilengedwe ndi amankhwala.
Kugwiritsa ntchito
Uracil ili ndi ntchito zingapo m'magawo osiyanasiyana, kuphatikiza:
Makampani Azamankhwala:Uracil ndi zotumphukira zake zakhala zikugwiritsidwa ntchito popanga mankhwala pazifukwa zosiyanasiyana. Mwachitsanzo, 5-fluorouracil ndi mankhwala omwe amagwiritsidwa ntchito kwambiri pochiza mitundu ina ya khansa. Mankhwala oletsa tizilombo toyambitsa matenda a Uracil, monga idoxuridine ndi trifluridine, amagwiritsidwa ntchito pochiza matenda a maso.
Agriculture:Zochokera ku Uracil zimagwiritsidwa ntchito popanga herbicides ndi fungicides. Mankhwalawa amathandizira kuletsa kukula kwa udzu komanso kuteteza mbewu ku matenda oyamba ndi fungus.
Analytical Chemistry:Uracil nthawi zambiri amagwiritsidwa ntchito ngati cholembera cha chromatographic kapena mulingo wamkati mu njira zowunikira zama chemistry. Itha kugwiritsidwa ntchito ngati chigawo chofotokozera kuti mudziwe nthawi yosungira komanso kuwerengera mankhwala ena muchitsanzo.
Kafukufuku wa Molecular Biology:Uracil imagwiritsidwa ntchito munjira zosiyanasiyana zama cell biology, monga polymerase chain reaction (PCR), DNA sequencing, ndi site-directed mutagenesis. Imakhala ngati template ya kaphatikizidwe ka DNA kapena ngati gawo lopanga masinthidwe enieni mumayendedwe a DNA.
Makampani a Chakudya:Uracil nthawi zina amagwiritsidwa ntchito ngati chowonjezera kukoma m'makampani azakudya, makamaka popanga zakudya ndi zakumwa.
Zodzoladzola:Zochokera ku Uracil zimagwiritsidwa ntchito popanga zodzikongoletsera kuti zikhale zonyowa komanso zotsitsimula khungu. Zitha kuthandizira kukonza kukhathamiritsa kwapakhungu komanso kuteteza ku zovuta zachilengedwe.
Kafukufuku ndi Chitukuko:Uracil amagwiritsidwanso ntchito pofufuza zamankhwala ndi zamankhwala monga reagent kapena apakatikati popanga zinthu zina zokhala ndi zochitika zamoyo kapena powerenga ma nucleic acid metabolism.
Ntchito zosiyanasiyana za Uracil zikuwonetsa kufunikira kwake m'magawo monga zamankhwala, ulimi, chemistry, ndi biotechnology. Ofufuza akupitiriza kufufuza njira zatsopano zogwiritsira ntchito katundu wake kuti apite patsogolo m'madera awa.
